Rao B K, Weir G J, Lieberman L M
Clin Nucl Med. 1981 Jul;6(7):289-94. doi: 10.1097/00003072-198107000-00001.
Tc-99m-sulfur colloid scintigrams were abnormal in four patients with hepatic dysfunction due to chronic alcohol abuse. Minimal uptake of radiocolloid in the liver suggested local reticuloendothelial (RE) cell failure. Imaging with a new hepatobiliary agent, Tc-99m-PIPIDA, revealed rapid hepatic accumulation and excretion of radiotracer with adequate visualization of the organ. Scintigraphic findings in these patients indicated a dissociation of hepatocyte and RE cell functions. Demonstration of adequate hepatocyte function with severe RE failure in alcoholic liver disease using a Tc-99m-labeled hepatobiliary agent has not been previously reported.
对于4例因长期酗酒导致肝功能不全的患者，锝-99m-硫胶体闪烁扫描结果异常。肝脏对放射性胶体摄取极少，提示局部网状内皮（RE）细胞功能衰竭。使用新型肝胆显像剂锝-99m-PIPIDA进行显像，结果显示放射性示踪剂在肝脏快速蓄积和排泄，肝脏显像良好。这些患者的闪烁扫描结果表明肝细胞和RE细胞功能分离。此前尚未有报道使用锝-99m标记的肝胆显像剂在酒精性肝病中证实存在严重RE功能衰竭但肝细胞功能正常的情况。
