Zakay-Rones Z, Hadas O, Levy R
Med Microbiol Immunol. 1978 Nov 17;166(1-4):43-50. doi: 10.1007/BF02121133.
The present study describes the respiratory immune response of mice to locally administered antigen, and the modulation of this response by systemic immunization. Intranasal immunization of mice with the A/PR/8/34 strain of influenza virus evoked local antibody response of the IgA type. The titer of the IgA antibodies declined to a nondetectable level in 40--50 days. If at that time a second intranasal dose was administered, a secondary IgA response was evoked. On the other hand, administration by the intramuscular route resulted in a mixed population of IgA and IgG antibodies. The relevance of this finding to problems of immunization against respiratory viral infections is discussed.
本研究描述了小鼠对局部给予抗原的呼吸道免疫反应，以及全身免疫对该反应的调节。用A/PR/8/34流感病毒株对小鼠进行鼻内免疫可诱发IgA类型的局部抗体反应。IgA抗体滴度在40 - 50天内降至不可检测水平。如果在那时给予第二次鼻内剂量，则会诱发继发性IgA反应。另一方面，通过肌肉途径给药则导致IgA和IgG抗体的混合群体。讨论了这一发现与呼吸道病毒感染免疫问题的相关性。
