Owen J P, Keir M J, Nair K V, Lauckner D, Wilsdon J B
Clin Radiol. 1981 May;32(3):341-6. doi: 10.1016/s0009-9260(81)80061-x.
In a comparative urographic study of the methylglucamine salts of iodamide (Uromiro 300) and iothalamate (Conray 280) the following conclusions have been made: (i) In subjects with radiologically normal kidneys and a creatinine clearance greater than 70 ml/min total urogram scores and nephrogram scores were higher with iodamide (not statistically significant). The improvement in performance was more marked in the nephrographic phase. (ii) In patients with radiologically normal kidneys and a spectrum of normal and abnormal renal function, total urogram scores and nephrogram scores showed no significant dependance on creatinine clearance. (iii) No correlations of note were observed between urographic performance and physical or biochemical parameters for either contrast medium. (iv) Side effects encountered in the study were mild and there were no significant differences between the contrast media in either the incidence or severity of the side effects. (v) Post-injection blood pressure profiles showed no significant differences between the media. (vi) Induced electrocardiographic abnormalities were uncommon and mild occurring in seven patients following iothalamate and three patients following iodamide.
在一项关于碘他拉胺（优维显300）和碘肽葡胺（康瑞280）的甲基葡胺盐的比较尿路造影研究中，得出了以下结论：（i）在肾脏放射学检查正常且肌酐清除率大于70 ml/min的受试者中，碘他拉胺的全尿路造影评分和肾造影评分更高（无统计学意义）。在肾造影阶段，性能改善更为明显。（ii）在肾脏放射学检查正常且肾功能正常和异常范围的患者中，全尿路造影评分和肾造影评分与肌酐清除率无显著相关性。（iii）两种造影剂的尿路造影性能与物理或生化参数之间均未观察到显著相关性。（iv）研究中遇到的副作用较轻，两种造影剂在副作用的发生率或严重程度上均无显著差异。（v）注射后血压曲线在两种造影剂之间无显著差异。（vi）诱发的心电图异常不常见且轻微，碘肽葡胺后有7例患者出现，碘他拉胺后有3例患者出现。
