Vaziri N D, Thomas R, Sterling M, Seiff K, Pahl M V, Davila J, Wilson A
Clin Toxicol. 1981 Mar;18(3):353-66. doi: 10.3109/15563658108990042.
Intravenous injection of crude marijuana extract led to development of an acute illness with multisystem involvement. Gastrointestinal manifestations consisted of severe vomiting, diarrhea, and crampy abdominal pain. Hypotension, tachycardia, and peripheral vasodilation constituted the main cardiovascular manifestations of the disease. Moderate azotemia and oliguria, presumed to be of prerenal origin, were present and rapidly resolved with administration of intravenous fluids. Hematologic manifestations consisted of leukocytosis with a left shift, thrombocytopenia, prolonged partial thromboplastin time, increased fibrin degradation products, and positive protamine sulfate test. The observed coagulation abnormalities may suggest intravascular coagulation. C3, C4, and total hemolytic complement were reduced, suggesting possible activation of the complement system. Hyperventilation, hypoxemia, pulmonary edema, obstructive, and restrictive pulmonary function abnormalities and bilateral pleural effusions highlighted the pulmonary manifestations of the disease. Rhadbomyolysis and mild hepatic function abnormalities were also present. All observed abnormalities reversed in a few days with no significant sequelae.
静脉注射大麻粗提物导致出现一种累及多系统的急性疾病。胃肠道表现包括严重呕吐、腹泻和痉挛性腹痛。低血压、心动过速和外周血管舒张是该疾病的主要心血管表现。存在中度氮质血症和少尿，推测为肾前性，静脉补液后迅速缓解。血液学表现包括白细胞增多伴核左移、血小板减少、部分凝血活酶时间延长、纤维蛋白降解产物增加以及硫酸鱼精蛋白试验阳性。观察到的凝血异常可能提示血管内凝血。C3、C4和总溶血补体降低，提示补体系统可能被激活。过度通气、低氧血症、肺水肿、阻塞性和限制性肺功能异常以及双侧胸腔积液突出了该疾病的肺部表现。还存在横纹肌溶解和轻度肝功能异常。所有观察到的异常在数天内逆转，无明显后遗症。
