Yen P M, Tashjian A H
Endocrinology. 1981 Jul;109(1):17-22. doi: 10.1210/endo-109-1-17.
Treatment of GH3 cells for 24-72 h with sodium valerate (1 mM) increased 2- to 4-fold the production of both PRL and GH. There was a concomitant change in the morphology of the cells that resembled that produced by TRH and epidermal growth factor. The increases in hormone production and changes in morphology were reversible. The sodium salts of butyric, hexanoic, caprylic, nonanoic, and dodecanoic acids also increased hormone production and altered cell morphology, whereas the salts of formic, acetic, and isobutyric acids did not. Acute (1-h) treatment with the fatty acids, unlike the effects of TRH and epidermal growth factor, did not increase the release of PRL from the cells.
用戊酸钠（1 mM）处理GH3细胞24至72小时，可使催乳素（PRL）和生长激素（GH）的分泌增加2至4倍。细胞形态同时发生变化，类似于促甲状腺激素释放激素（TRH）和表皮生长因子所产生的变化。激素分泌的增加和形态变化是可逆的。丁酸、己酸、辛酸、壬酸和十二烷酸的钠盐也增加了激素分泌并改变了细胞形态，而甲酸、乙酸和异丁酸的盐则没有此作用。与TRH和表皮生长因子的作用不同，脂肪酸急性（1小时）处理并未增加细胞中PRL的释放。
