Thompson E B
Environ Health Perspect. 1981 Apr;38:99-103. doi: 10.1289/ehp.813899.
This paper will briefly outline those elements which must be considered in assessing the effects of any given compound which might impinge on the actions of adrenocortical steroids. Considerations that ought to be taken into account include the following: the delivery to the affected cells of corticosteroids, the uptake of the hormone by the cells, the metabolism of the hormone by the cells, the intracellular actions of the hormone, the possible secondary interactions between cells, and multihormonal actions on the final target cell.
本文将简要概述在评估任何可能影响肾上腺皮质类固醇作用的特定化合物的效应时必须考虑的那些因素。应予以考虑的因素包括以下几点：皮质类固醇向受影响细胞的递送、细胞对激素的摄取、细胞对激素的代谢、激素在细胞内的作用、细胞间可能的次级相互作用以及对最终靶细胞的多激素作用。
