Junker S, Chemnitz J
Eur J Cell Biol. 1981 Apr;24(1):16-9.
This report describes a transmission electron microscopic study on hybrids between subhexaploid mouse melanoma cells and subtetraploid mouse fibroblasts. The melanoma cell line was heterogeneous in terms of pigment production, but all cells contained melanosomes, although in different stages of development. Characteristic features of the fibroblasts included the cytoskeleton, endocytic vesicles, and occurrence of dilated cisternae of granular endoplasmic reticulum. Despite the gene dosage in favour of the melanoma parent cell, the hybrids were devoid of melanosomes, and their phenotype was typically fibroblastic in character.
本报告描述了对亚六倍体小鼠黑色素瘤细胞与亚四倍体小鼠成纤维细胞之间杂种的透射电子显微镜研究。黑色素瘤细胞系在色素产生方面具有异质性，但所有细胞均含有黑素小体，尽管处于不同的发育阶段。成纤维细胞的特征包括细胞骨架、内吞小泡以及颗粒内质网扩张池的出现。尽管基因剂量有利于黑色素瘤亲代细胞，但杂种缺乏黑素小体，其表型典型地具有成纤维细胞特征。
