Poulain D A, Lebrun C J, Vincent J D
Exp Brain Res. 1981;42(3-4):260-8. doi: 10.1007/BF00237493.
In order to see whether septal neurones are connected to the hypothalamic neurones secreting vasopressin or oxytocin, neurones in different regions of the septum were recorded during electrical stimulation of the supraoptic nucleus. The position of the stimulating electrode within the latter was verified using lactating rats in which milk ejections could be induced by a train of electrical pulses applied to the nucleus. The responses of septal neurones to single pulse stimulation were then analysed by post-stimulus time histograms. In the septum ipsilateral to the site of stimulation, 42% of the neurones were antidromically invaded, 20% were orthodromically excited and 21% were inhibited following suraoptic stimulation. In the contralateral septum, 2% of the cells tested were antidromically invaded, 3% were excited and 16% inhibited. In the medial septum, 14% of the neurones were orthodromically excited, and 48% were inhibited. These results provide electrophysiological evidence for direct connections between septal neurones and the ipsilateral supraoptic nucleus of the hypothalamus, and give further support to the hypothesis of a septal influence on the activity of vasopressin- or oxytocin-releasing cells in the magnocellular system.
为了观察隔区神经元是否与分泌抗利尿激素或催产素的下丘脑神经元相连，在电刺激视上核时记录隔区不同区域的神经元。利用泌乳大鼠来验证刺激电极在视上核内的位置，在泌乳大鼠中，施加于视上核的一串电脉冲可诱发喷乳。然后通过刺激后时间直方图分析隔区神经元对单脉冲刺激的反应。在刺激部位同侧的隔区，42%的神经元被逆行侵入，20%被顺行兴奋，视上核刺激后21%被抑制。在对侧隔区，2%受试细胞被逆行侵入，3%被兴奋，16%被抑制。在内侧隔区，14%的神经元被顺行兴奋，48%被抑制。这些结果为隔区神经元与同侧下丘脑视上核之间的直接联系提供了电生理证据，并进一步支持了隔区对大细胞系统中抗利尿激素或催产素释放细胞活动有影响的假说。
