Brommer E J
J Int Med Res. 1981;9(3):203-10. doi: 10.1177/030006058100900310.
In order to study in its protective effect against post-operative thrombosis, Ticlopidine was administered to one out of two randomized groups of patients undergoing suprapubic prostatectomy. Bleeding time, platelet function, and haematological parameters were followed. Blood loss during operation and post-operatively were estimated, transfusions required and subjective tolerance were recorded. Among twenty-six evaluated patients receiving Ticlopidine, positive leg scans were found in four, whereas among twenty patients treated with acenocoumarol post-operatively, positive leg scans were found in seven patients. The difference is not statistically significant, thus Ticlopidine appears to offer a protection against deep venous thrombosis comparable to that of acenocoumarol. A score is introduced for comparison of the results of aggregation tests. Platelet aggregability diminished during the use of the drug, but the adhesiveness was not influenced by Ticlopidine. The bleeding time was prolonged in both groups studied. Ticlopidine did not raise per-operative blood loss and caused only slightly more haematuria post-operatively. The subjective tolerance was good.
为研究噻氯匹定对耻骨上前列腺切除术后血栓形成的保护作用，将其给予两组随机分组接受耻骨上前列腺切除术患者中的一组。对出血时间、血小板功能和血液学参数进行跟踪。估计手术期间和术后的失血量，记录所需输血情况和主观耐受性。在26例接受噻氯匹定治疗的评估患者中，4例腿部扫描呈阳性，而在20例术后接受醋硝香豆素治疗的患者中，7例腿部扫描呈阳性。差异无统计学意义，因此噻氯匹定似乎提供了与醋硝香豆素相当的预防深静脉血栓形成的保护作用。引入一个评分用于比较聚集试验结果。用药期间血小板聚集性降低，但噻氯匹定不影响血小板黏附性。研究的两组出血时间均延长。噻氯匹定未增加术中失血量，术后仅导致稍多的血尿。主观耐受性良好。
