Kroft L J, de Maat M P, Brommer E J
Dept. of Internal Medicine II, University Hospital Dijkzigt, Rotterdam, The Netherlands.
Thromb Res. 1993 May 15;70(4):349-54. doi: 10.1016/0049-3848(93)90108-z.
The mechanisms of the antithrombotic effect of the platelet aggregation inhibiting agent Ticlopidine might include a decrease of the plasma fibrinogen level. The effect of ticlopidine on increased fibrinogen synthesis following trauma, such as surgery, is however not known. 46 patients who underwent suprapubic prostatectomy were randomized to receive either (group A) Ticlopidine (2 x 250 mg daily) from the second preoperative day until the seventh postoperative day or (group B) placebo up till the day of surgery and further acenocoumarol against post-operatively and observed that the level and in particular the rise of the plasma fibrinogen concentration was not different in the two groups. It is concluded that compared with the standard treatment in group B ticlopidine does not influence trauma-induced fibrinogen increase.
血小板聚集抑制剂噻氯匹定的抗血栓形成作用机制可能包括降低血浆纤维蛋白原水平。然而，噻氯匹定对创伤（如手术）后纤维蛋白原合成增加的影响尚不清楚。46例行耻骨上前列腺切除术的患者被随机分为两组，A组从术前第二天至术后第七天接受噻氯匹定（每日2次，每次250mg），B组在手术当天前接受安慰剂，术后接受醋硝香豆素，并观察到两组血浆纤维蛋白原浓度水平，特别是其升高情况并无差异。得出的结论是，与B组的标准治疗相比，噻氯匹定不影响创伤引起的纤维蛋白原增加。
