Scognamiglio R, Chioin R, Stritoni P, Razzolini R, Daliento L, Corbara F, Boffa G M
G Ital Cardiol. 1981;11(1):51-7.
Have been studied 51 patients with aortic incompetency (AI), 46 with mitral insufficiency (MI) and 31 with congestive cardiomyopathy (CM) as example of a primitive myocardial lesion. The mean parametres calculated were: the left ventricular end-diastolic pressure (LVEDP), the ventricular volumes, the ejection fraction (EF), the end-sistolic pressure-volume ratio (Emax) and the eccentricity. In the chronic volume overload, the relationship between the pump performance and the contractility (EF-Emax) is parabolic with an initial plateau (myocardial failure without circulatory failure); the EF-Emax relationship, in the CM, is linear without a plateau. The LVEDP is a limiting factor of the pump-contractility relationship in the AI: for the same value of the contractility, the pump function is greater depressed if the LVEDP is 25 mmHg (loss of the preload modulation); in the MI and CM the depression of the pump performance is a function only of the depressed contractility. The end-systolic eccentricity is correlated with Emax: the changes in the geometrical shape of the left ventricular chamber is due to the depressed contractility.
已对51例主动脉瓣关闭不全（AI）患者、46例二尖瓣关闭不全（MI）患者和31例充血性心肌病（CM）患者进行了研究，这些患者作为原发性心肌病变的实例。计算出的平均参数有：左心室舒张末期压力（LVEDP）、心室容积、射血分数（EF）、收缩末期压力-容积比（Emax）和偏心度。在慢性容量超负荷情况下，泵功能与收缩性（EF-Emax）之间的关系呈抛物线形，起始有一平台期（无循环衰竭的心肌衰竭）；在CM中，EF-Emax关系呈线性，无平台期。LVEDP是AI中泵-收缩性关系的一个限制因素：对于相同的收缩性值，如果LVEDP为25 mmHg，泵功能的抑制作用会更强（前负荷调节丧失）；在MI和CM中，泵功能的抑制仅取决于收缩性的降低。收缩末期偏心度与Emax相关：左心室腔几何形状的改变是由于收缩性降低所致。
