Winek C L, Cibulas W, Wahba W W
Forensic Sci Int. 1981 May-Jun;17(3):197-202. doi: 10.1016/0379-0738(81)90167-5.
Bone marrow may be utilized as an alternative biological sample in cases where uncontaminated blood samples are not available for analyses. Bone marrow/blood ratios of ethchlorvynol as a function of time and dosage level were determined in 40 rabbits. A modified quantitative analysis that produced accurate and reproducible results was employed for the determination of ethchlorvynol levels. Further, ten blood and bone marrow samples containing ethchlorvynol were chosen to study the effects of storage for a period of 24 hours. Studies of blood and bone marrow ethchlorvynol levels with time showed no linear relationship. Bone marrow/blood ratios as a function of dose resulted in close mean averages with a wide range of values. Significant losses in both blood and bone marrow ethchlorvynol levels were evidenced in most of the samples subjected to the 24-hour storage study.
在无法获得未受污染的血液样本进行分析的情况下，骨髓可用作替代生物样本。测定了40只兔子体内乙氯维诺的骨髓/血液比率随时间和剂量水平的变化。采用了一种能产生准确且可重复结果的改良定量分析方法来测定乙氯维诺水平。此外，选择了10份含有乙氯维诺的血液和骨髓样本，研究储存24小时的影响。血液和骨髓中乙氯维诺水平随时间的研究表明不存在线性关系。骨髓/血液比率随剂量的变化导致平均值相近，但数值范围较宽。在大多数进行24小时储存研究的样本中，血液和骨髓中的乙氯维诺水平均有显著损失。
