Fekety K B, Medwick T
J Pharm Sci. 1983 Nov;72(11):1358-60. doi: 10.1002/jps.2600721133.
A quantitative 1H-NMR procedure is described for measuring ethchlorvynol in capsules. Deuterochloroform is used as the solvent, and hexamethylenetetramine as the internal standard; the analysis is based on the comparison of the area of the AB peak system of ethchlorvynol with the area of the hexamethylenetetramine singlet. The 1H-NMR method yields results that are precise to within 1% and agree well with results of the more cumbersome and less specific USP titrimetric procedure.
本文描述了一种用于测定胶囊中乙氯维诺的定量1H-NMR方法。使用氘代氯仿作为溶剂，六亚甲基四胺作为内标；该分析基于乙氯维诺的AB峰系统面积与六亚甲基四胺单峰面积的比较。1H-NMR方法的结果精确到1%以内，与更繁琐且特异性较低的USP滴定法结果吻合良好。
