Graf U, Marbet U, Müller W, Thiel G
Immun Infekt. 1981 Mar;9(1):20-8.
The treatment of rheumatoid arthritis and psoriatic arthritis with cyclosporin A is described. Cyslosporin A is a new selective immunosuppressant which acts primarily on the T lymphocytes. It has already been shown to be effective in preventing rejection following kidney transplantation as well as in preventing graft-versus-host disease. In rheumatoid and psoriatic arthritis, however, its effect was not satisfactory, although rather different in the two conditions; overall only about one third of the patients showed any marked improvement. By contrast, and for reasons which are as yet unexplained, it had a beneficial effect on the cutaneous symptoms of psoriasis. Cyclosporin A had little effect on immune parameters. Side effects--mainly kidney toxicity, gastro-intestinal reactions and hirsutism--were common but reversible. On present evidence its principal indication among rheumatological diseases would seem to be as a treatment for severe, intractable psoriatic arthritis.
本文描述了用环孢素A治疗类风湿性关节炎和银屑病关节炎的情况。环孢素A是一种新型选择性免疫抑制剂，主要作用于T淋巴细胞。它已被证明在预防肾移植后的排斥反应以及预防移植物抗宿主病方面有效。然而，在类风湿性关节炎和银屑病关节炎中，其效果并不令人满意，尽管在这两种疾病中的表现有所不同；总体而言，只有约三分之一的患者有明显改善。相比之下，出于尚未解释的原因，它对银屑病的皮肤症状有有益作用。环孢素A对免疫参数影响很小。副作用——主要是肾毒性、胃肠道反应和多毛症——很常见但可逆转。根据目前的证据，在风湿性疾病中，其主要适应证似乎是作为重度、难治性银屑病关节炎的一种治疗方法。
