Marbet U A, Graf U, Mihatsch M J, Gratwohl A, Müller W, Thiel G
Schweiz Med Wochenschr. 1980 Dec 27;110(52):2017-20.
Renal function was studied prospectively in 6 patients with rheumatoid arthritis and non-prospectively in 5 patients after bone marrow transplantation. Both groups were treated with cyclosporin A. Functionally and histologically the results suggest tubulotoxicity of cyclosporin A which seems to be dose-related and reversible. Also found in the urine of these patients were yellow, as yet undescribed crystalline bodies often included in casts.
对6例类风湿性关节炎患者的肾功能进行了前瞻性研究，对5例骨髓移植后的患者进行了非前瞻性研究。两组均接受环孢素A治疗。在功能和组织学方面，结果提示环孢素A具有肾小管毒性，这似乎与剂量相关且可逆。在这些患者的尿液中还发现了黄色的、尚未描述的晶体，这些晶体常包含在管型中。
