Davies R
IARC Sci Publ. 1980(30):419-25.
The release of enzymes from mouse peritoneal macrophages exposed to amphibole asbestos, man-made mineral fibres and nonsilicate mineral fibres, was examined. All materials caused the release of the cytoplasmic enzyme lactic dehydrogenase and also caused the release of significantly higher levels of the lysosomal enzyme beta-glucuronidase. In some instances, the fibrous nature of the minerals was important for their activities. The release of enzymes from the cells appears to correlate with the fibrogenicity of the minerals in vivo.
研究了暴露于闪石石棉、人造矿物纤维和非硅酸盐矿物纤维的小鼠腹腔巨噬细胞中酶的释放情况。所有材料均导致细胞质酶乳酸脱氢酶的释放，并且还导致溶酶体酶β-葡萄糖醛酸酶的释放水平显著更高。在某些情况下，矿物的纤维性质对其活性很重要。细胞中酶的释放似乎与矿物在体内的致纤维化能力相关。
