Pololi-Anagnostou L, Schade S, Anagnostou A
Int J Vitam Nutr Res. 1981;51(1):59-63.
The anemia of protein deprivation is due mainly to a decrease in erythropoietin (Ep) production. In this study we investigated the effect of protein deprivation on the number of erythroid stem cells (CFU-E, BFU-E). Mice given a protein-free diet for six days had significantly fewer CFU-E and BFU-E numbers per femur compared to mice given a diet with normal protein content. The decrease in BFU-E cannot be ascribed solely to decreased Ep production and occurs before changes in the femoral multipotential haematopoietic stem cells (CFU-S).
蛋白质缺乏性贫血主要是由于促红细胞生成素（Ep）生成减少所致。在本研究中，我们调查了蛋白质缺乏对红系干细胞（CFU-E、BFU-E）数量的影响。与给予正常蛋白质含量饮食的小鼠相比，给予无蛋白饮食六天的小鼠每根股骨中的CFU-E和BFU-E数量显著减少。BFU-E的减少不能仅仅归因于Ep生成的减少，并且发生在股骨多能造血干细胞（CFU-S）发生变化之前。
