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Methotrexate resistance in al L1210 cell line resulting from increased dihydrofolate reductase, decreased thymidylate synthetase activity, and normal membrane transport. Computer simulations based on network thermodynamics.

作者信息

White J C, Goldman I D

出版信息

J Biol Chem. 1981 Jun 10;256(11):5722-7.

PMID:7240168
Abstract
摘要

相似文献

1
Methotrexate resistance in al L1210 cell line resulting from increased dihydrofolate reductase, decreased thymidylate synthetase activity, and normal membrane transport. Computer simulations based on network thermodynamics.由于二氢叶酸还原酶增加、胸苷酸合成酶活性降低以及正常的膜转运导致的L1210细胞系中甲氨蝶呤耐药性。基于网络热力学的计算机模拟。
J Biol Chem. 1981 Jun 10;256(11):5722-7.
2
Interaction of thymidylate synthetase and dihydrofolate reductase enzymes in vitro and in vivo.胸苷酸合成酶与二氢叶酸还原酶在体外和体内的相互作用。
Cancer Res. 1974 Jul;34(7):1619-26.
3
Evidence for a functional defect in the translocation of the methotrexate transport carrier in a methotrexate-resistant murine L1210 leukemia cell line.甲氨蝶呤耐药小鼠L1210白血病细胞系中甲氨蝶呤转运载体易位功能缺陷的证据。
J Biol Chem. 1988 Jul 15;263(20):9840-7.
4
Predictions of a network thermodynamics computer model relating to the mechanism of methotrexate rescue by 5-formyltetrahydrofolate and to the importance of inhibition of thymidylate synthase by methotrexate-polyglutamates.一个网络热力学计算机模型的预测，该模型涉及5-甲酰四氢叶酸对甲氨蝶呤的解救机制以及甲氨蝶呤多聚谷氨酸对胸苷酸合成酶抑制作用的重要性。
Adv Exp Med Biol. 1983;163:305-26. doi: 10.1007/978-1-4757-5241-0_23.
5
Elevation of dihydrofolate reductase, thymidylate synthetase, and thymidine kinase in cultured mammalian cells after exposure to folate antagonists.暴露于叶酸拮抗剂后培养的哺乳动物细胞中二氢叶酸还原酶、胸苷酸合成酶和胸苷激酶的升高。
Cancer Res. 1976 Jul;36(7 PT 1):2442-9.
6
Resistance of Pediococcus cerevisiae to amethopterin as a consequence of changes in enzymatic activity and cell permeability. I. Dihydrofolate reductase, thymidylate synthetase and formyltetrahydrofolate synthetase in amethopterin-resistant and -sensitive strains of Pediococcus cerevisiae.啤酒片球菌对氨甲蝶呤的抗性与酶活性和细胞通透性变化的关系。I. 啤酒片球菌氨甲蝶呤抗性和敏感菌株中的二氢叶酸还原酶、胸苷酸合成酶和甲酰四氢叶酸合成酶
Biochim Biophys Acta. 1976 May 28;428(3):664-73. doi: 10.1016/0304-4165(76)90196-3.
7
Membrane protein changes in an L1210 leukemia cell line with a translocation defect in the methotrexate-tetrahydrofolate cofactor transport carrier.在甲氨蝶呤 - 四氢叶酸辅因子转运载体存在易位缺陷的L1210白血病细胞系中的膜蛋白变化
J Biol Chem. 1989 Sep 25;264(27):16261-7.
8
Effects of 5,8-dideazaisopteroylglutamate and its possible tri-gamma-glutamyl metabolite (5,8-dideazaisoPteGlu3) on colon adenocarcinoma, and the folate dependent enzymes thymidylate synthase and dihydrofolate reductase.5,8-二去氮异喋呤谷氨酸及其可能的三γ-谷氨酰代谢产物（5,8-二去氮异喋呤谷氨酸3）对结肠腺癌以及叶酸依赖性酶胸苷酸合成酶和二氢叶酸还原酶的影响。
Adv Exp Med Biol. 1983;163:341-57. doi: 10.1007/978-1-4757-5241-0_25.
9
A comparison of dihydrofolate reductase activity in intact leukemia cells and squamous cell carcinoma.完整白血病细胞与鳞状细胞癌中二氢叶酸还原酶活性的比较。
Anticancer Drug Des. 1989 Jun;4(1):79-87.
10
Intrinsic resistance to methotrexate of cultured mammalian cells in relation to the inhibition kinetics of their dihydrololate reductases.培养的哺乳动物细胞对甲氨蝶呤的内在抗性与其二氢叶酸还原酶的抑制动力学的关系。
Cancer Res. 1976 Jun;36(6):1991-7.

引用本文的文献

1
Methotrexate delivery via folate targeted dendrimer-based nanotherapeutic platform.叶酸靶向树枝状大分子纳米治疗平台递药系统治疗甲氨蝶呤。
Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2009 Sep-Oct;1(5):502-10. doi: 10.1002/wnan.37.
2
Immucillin H, a powerful transition-state analog inhibitor of purine nucleoside phosphorylase, selectively inhibits human T lymphocytes.免疫胞苷H是一种嘌呤核苷磷酸化酶的强效过渡态类似物抑制剂，可选择性抑制人T淋巴细胞。
Proc Natl Acad Sci U S A. 2001 Apr 10;98(8):4593-8. doi: 10.1073/pnas.071050798. Epub 2001 Apr 3.
3
Effect of hammerhead ribozyme against human thymidylate synthase on the cytotoxicity of thymidylate synthase inhibitors.
锤头状核酶作用于人类胸苷酸合成酶对胸苷酸合成酶抑制剂细胞毒性的影响。
Jpn J Cancer Res. 1995 Nov;86(11):1014-8. doi: 10.1111/j.1349-7006.1995.tb03014.x.
4
Determinants of trimetrexate lethality in human colon cancer cells.三甲曲沙对人结肠癌细胞致死性的决定因素。
Br J Cancer. 1994 Dec;70(6):1075-84. doi: 10.1038/bjc.1994.451.
5
Response of methylenetetrahydrofolate levels to methotrexate in Krebs ascites cells.克氏腹水癌细胞中亚甲基四氢叶酸水平对甲氨蝶呤的反应。
Biochem J. 1983 Nov 15;216(2):295-8. doi: 10.1042/bj2160295.
6
Use of the circuit simulation program SPICE2 for analysis of the metabolism of anticancer drugs.
Bull Math Biol. 1986;48(3-4):353-80. doi: 10.1007/BF02459687.
7
Impairment of methotrexate (MTX)-polyglutamate formation of MTX-resistant K562 cell lines.甲氨蝶呤（MTX）耐药的K562细胞系中甲氨蝶呤（MTX）-多聚谷氨酸形成受损。
Jpn J Cancer Res. 1988 Nov;79(11):1230-7. doi: 10.1111/j.1349-7006.1988.tb01549.x.
8
Determinants of the sensitivity of human small-cell lung cancer cell lines to methotrexate.人小细胞肺癌细胞系对甲氨蝶呤敏感性的决定因素。
J Clin Invest. 1985 Oct;76(4):1323-9. doi: 10.1172/JCI112106.