Tsunoda S, Gega A, Utsumi S, Matsuoka Y, Kubota C
No Shinkei Geka. 1978 Oct;6(10):971-4.
Uric acid is the end-product of purine metabolism, and purines are the nitrogenous bases derived from the breakdown of nucleic acids. The CSF uric acid level is thought to be the index of the turnover of the nucleic acid and the degree of the cellular destruction in the brain. CSF uric acid levels were investigated in normal controls (30 cases) and in patients with brain tumor (20 cases), microcephalus (8 cases) and craniostenosis (4 cases). The mean values and standard deviations of CSF uric acid levels in normal controls were as follows; Newborn--9 yrs 0.34 +/- 0.09 mg/dl; 10 yrs--19 yrs 0.50 +/- 0.18 mg/dl; 20 yrs--29 yrs 0.46 +/- 0.05 mg/dl; 30 yrs--39 yrs 0.35 +/- 0.10 mg/dl; 40 yrs--49 yrs 0.35 +/- 0.23 mg/dl. Thereafter 0.72 +/- 0.21 mg/dl. The increased CSF uric acid levels after the age of 50 is thought to be due to the cellular destruction in the brain. CSF uric acid levels increased in patients with highly malignant brain tumor such as grade 3 or 4 astrocytoma and sarcomatous meningioma, but were normal in patients with grade 2 astrocytoma and meningiomas of meingothelial or fibroblastic type. CSF uric acid levels decreased in patients with microcephalus, but were almost normal in patients with craniostenosis. There is a significant correlation between CSF uric acid levels and the degree of brain atrophy in infants.
尿酸是嘌呤代谢的终产物，而嘌呤是核酸分解产生的含氮碱基。脑脊液尿酸水平被认为是核酸周转率及脑内细胞破坏程度的指标。对30例正常对照者、20例脑肿瘤患者、8例小头畸形患者及4例颅骨狭窄患者的脑脊液尿酸水平进行了研究。正常对照者脑脊液尿酸水平的平均值及标准差如下：新生儿至9岁为0.34±0.09mg/dl；10岁至19岁为0.50±0.18mg/dl；20岁至29岁为0.46±0.05mg/dl；30岁至39岁为0.35±0.10mg/dl；40岁至49岁为0.35±0.23mg/dl。此后为0.72±0.21mg/dl。50岁以后脑脊液尿酸水平升高被认为是由于脑内细胞破坏所致。高度恶性脑肿瘤患者，如3级或4级星形细胞瘤及肉瘤样脑膜瘤患者的脑脊液尿酸水平升高，但2级星形细胞瘤及内皮型或纤维母细胞型脑膜瘤患者的脑脊液尿酸水平正常。小头畸形患者的脑脊液尿酸水平降低，但颅骨狭窄患者的脑脊液尿酸水平几乎正常。婴儿脑脊液尿酸水平与脑萎缩程度之间存在显著相关性。
