Phillips P C, Kremzner L T, De Vivo D C
Ann Neurol. 1986 Apr;19(4):360-4. doi: 10.1002/ana.410190409.
The clinical value of cerebrospinal fluid (CSF) polyamine determinations in childhood medulloblastoma has been suggested. We performed 72 CSF polyamine determinations in 35 children with primary brain tumors. Spermine values were normal and spermidine values were inconsistently elevated. CSF putrescine values, however, were consistently elevated in patients with histologically malignant brain tumors: medulloblastoma, ependymoma, pineal germ cell tumors, primitive neuroectodermal tumors, and brainstem gliomas. Children with supratentorial astrocytomas had normal CSF polyamine values. CSF putrescine values were closely correlated with clinical state, with the highest concentrations identified in patients with widely disseminated recurrent disease. We found CSF putrescine to be a sensitive indicator of active disease in childhood malignant brain tumors. Further investigation is warranted into the predictive value of CSF polyamines in determining tumor relapse before clinical or other diagnostic studies reveal recurrent disease.
脑脊液（CSF）多胺测定在儿童髓母细胞瘤中的临床价值已得到提示。我们对35例原发性脑肿瘤患儿进行了72次脑脊液多胺测定。精胺值正常，亚精胺值升高情况不一致。然而，组织学上为恶性脑肿瘤（髓母细胞瘤、室管膜瘤、松果体生殖细胞瘤、原始神经外胚层肿瘤和脑干胶质瘤）的患者脑脊液腐胺值持续升高。幕上星形细胞瘤患儿脑脊液多胺值正常。脑脊液腐胺值与临床状态密切相关，在广泛播散性复发性疾病患者中浓度最高。我们发现脑脊液腐胺是儿童恶性脑肿瘤活动性疾病的敏感指标。在临床或其他诊断研究发现复发性疾病之前，有必要进一步研究脑脊液多胺在确定肿瘤复发方面的预测价值。
