对BALB/c纤维肉瘤Meth-A抗性的非H-2连锁基因控制

Non-H-2-linked genetic control of resistance to BALB/c fibrosarcoma Meth-A.

作者信息

Mizushima Y, Sendo F, Takeichi N, Kobayashi H

出版信息

J Immunogenet. 1980 Dec;7(6):447-53. doi: 10.1111/j.1744-313x.1980.tb00740.x.

DOI:10.1111/j.1744-313x.1980.tb00740.x

Abstract

The genetic control of hybrid resistance to BALB/c fibrosarcoma Meth-A was investigated. A Meth-A tumour grew slower in (BALB/c x C57BL/6)F1 and reciprocal hybrid mice than in syngeneic BALB/c mice and was also found to grow slower in females than in males. Significant F1 resistance was demonstrated after both subcutaneous and intraperitoneal injection of tumour cells. However, (BALB/c x DBA/2)F1 mice did not show any significant resistance to Meth-A. In H-2 linkage studies of [BALB/c x (BALB/c x C57BL/6)] backcross mice, no statistically significant differences in the resistance of H-2 heterozygotes and homozygotes to Meth-A were observed. These results indicated that F1 hybrid resistance to Meth-A was controlled by non-H-2-linked resistance factor(s). No linkage was observed between resistance to Meth-A and coat colour c- and b-loci.

摘要

对BALB/c纤维肉瘤Meth-A的杂种抗性的遗传控制进行了研究。Meth-A肿瘤在（BALB/c×C57BL/6）F1代及正反交杂种小鼠中生长比在同基因BALB/c小鼠中慢，并且还发现其在雌性小鼠中比在雄性小鼠中生长慢。在皮下和腹腔注射肿瘤细胞后均显示出显著的F1抗性。然而，（BALB/c×DBA/2）F1代小鼠对Meth-A未表现出任何显著抗性。在[BALB/c×（BALB/c×C57BL/6）]回交小鼠的H-2连锁研究中，未观察到H-2杂合子和纯合子对Meth-A抗性的统计学显著差异。这些结果表明，F1代对Meth-A的杂种抗性由非H-2连锁的抗性因子控制。未观察到对Meth-A的抗性与毛色c和b位点之间存在连锁关系。