Henderson D C, Parker D, Turk J L
Immunology. 1980 Jan;39(1):1-9.
A comparison was made in mice between resistance to growth of a syngeneic methylcholanthrene-induced fibrosarcoma (Meth A) and specific delayed-type hypersensitivity to this tumour. Resistance could be induced in 90% of mice following a single injection of 10(4) Meth A cells. This resistance could be transferred by spleen cells but not serum. Delayed skin reactivity to ultrasonicated Meth A cells was found in both tumour-resistant and tumour-bearing mice and could be passively transferred by spleen cells and serum. These findings suggest a dissociation between tumour resistance and specific delayed-type hypersensitivity. It would appear that, in this system, delayed skin reactivity to Meth A tumour cells is mediated by humoral antibody despite a mononuclear cell infiltrate at 24 and 48 h and that this could be the reason for its lack of correlation with host resistance to tumour growth which is cell-mediated and not transferable by serum.
对同基因甲基胆蒽诱导的纤维肉瘤(Meth A)在小鼠体内的生长抗性与对该肿瘤的特异性迟发型超敏反应进行了比较。单次注射10⁴个Meth A细胞后,90%的小鼠可诱导出抗性。这种抗性可通过脾细胞而非血清进行转移。在抗瘤和荷瘤小鼠中均发现了对超声处理的Meth A细胞的迟发型皮肤反应性,且可通过脾细胞和血清进行被动转移。这些发现表明肿瘤抗性与特异性迟发型超敏反应之间存在分离。在该系统中,尽管在24小时和48小时时有单核细胞浸润,但对Meth A肿瘤细胞的迟发型皮肤反应性似乎是由体液抗体介导的,这可能是其与宿主对肿瘤生长的抗性缺乏相关性的原因,宿主对肿瘤生长的抗性是细胞介导的且不能通过血清转移。