Ejiri K
Nihon Sanka Fujinka Gakkai Zasshi. 1980 May;32(5):601-10.
The purpose of this paper is to investigate the specific metabolism of the protein and amino acid during pregnancy from a standpoint of urea nitrogen recycling hydrolyzed by intestinal bacterial urease of pregnant rat. For this purpose, the activity of urease of the intestinal flora, and L-glutamate dehydrogenase (GDH) in liver mitochondria, the concentration of free ammonia and urea in the intestinal tract, portal vein and right ventricle of the rat were discussed. The results were: 1) The activity of urease moderately increased during pregnancy with the peak on 19th gestational day. 2) The concentration of free ammonia in the intestinal tract elevated slightly, and markedly elevated in portal vein, but seemed to be no specific change in right ventricle. The peak showed on 19th gestational day. 3) The activity of GDH increased markedly during pregnancy, and the protein synthesis was thought to be accelerated. 4) Urea concentration in intestinal tract and blood stream seemed somewhat increased. This results revealed that the urea recycling system and protein synthesis accelerated during pregnancy because of high urease and GDH activity. This phenomenon adapted the pregnant to nutrient of the fetus for growing and development, and introduced a new concept of maternal-fetal unit of nutrition, especially in protein metabolism.
本文旨在从妊娠大鼠肠道细菌脲酶水解尿素氮循环的角度，研究孕期蛋白质和氨基酸的具体代谢情况。为此，讨论了肠道菌群脲酶活性、肝脏线粒体中的L-谷氨酸脱氢酶（GDH）活性、大鼠肠道、门静脉和右心室中游离氨和尿素的浓度。结果如下：1）孕期脲酶活性适度增加，在妊娠第19天达到峰值。2）肠道中游离氨浓度略有升高，门静脉中显著升高，但右心室似乎无特异性变化。峰值出现在妊娠第19天。3）孕期GDH活性显著增加，推测蛋白质合成加速。4）肠道和血流中的尿素浓度似乎有所增加。这些结果表明，由于脲酶和GDH活性较高，孕期尿素循环系统和蛋白质合成加速。这种现象使母体适应胎儿生长发育所需的营养，引入了母胎营养单位的新概念，尤其是在蛋白质代谢方面。
