Ochiai K
Nihon Sanka Fujinka Gakkai Zasshi. 1980 Jul;32(7):945-52.
The concentrations of cytosol estrogen receptor (ERc) and cytosol progesterone receptor (PRc) in the human endometrium, myometrium, fallopian tube, cervix, and myoma obtained from 20 patients have been measured by the dextran-coated charcoal method using estradiol-17 beta and R5020. The concentration of ERc of the endometrium and fallopian tube were significantly higher in the first half of proliferative phase compared to the other periods of the cycle (P less than 0.02). Significantly higher concentrations of PRc of the endometrium, myometrium and fallopian tube were obtained in the second half of proliferative phase (P less than 0.01). The ERc of the myometrium and the cervix, and the PRc of the cervix did not show any significant difference in the concentration during the proliferative phase, but mean values of the proliferative phase were higher than those of the secretory phase (P less than 0.05). Similar cyclic variations of ERc and PRc throughout the menstrual cycle was observed in small myoma, less than 3 cm in diameter. The concentration of ERc of small myoma in the first half of proliferative phase was three times higher than that of normal myometrium (P less than 0.01), but there was no significant difference in the concentration of PRc. Dissociation constants of ERc and PRc in all the tissue examined were in the range of 10(-10) and 10(-9) M, respectively, and did not fluctuate throughout the menstrual cycle. Results suggest that the endometrium, myometrium and fallopian tube are in a group and the cervix is different from them in terms of the pattern of variation in the concentration of ERc and PRc and the ratio of PRc to ERc (PRc/ERc) throughout the menstrual cycle. It is noteworthy that the PRc/ERc of small myoma was lower than normal myometrium, suggesting the possible relation to the pathological growth of myoma.
采用葡聚糖包被活性炭法，以雌二醇 - 17β和R5020测定了20例患者的人子宫内膜、子宫肌层、输卵管、宫颈和肌瘤中胞浆雌激素受体（ERc）和胞浆孕激素受体（PRc）的浓度。与月经周期的其他时期相比，增殖期前半期子宫内膜和输卵管的ERc浓度显著更高（P＜0.02）。增殖期后半期子宫内膜、子宫肌层和输卵管的PRc浓度显著更高（P＜0.01）。子宫肌层和宫颈的ERc以及宫颈的PRc在增殖期浓度无显著差异，但增殖期的平均值高于分泌期（P＜0.05）。在直径小于3 cm的小肌瘤中，观察到整个月经周期ERc和PRc有类似的周期性变化。增殖期前半期小肌瘤的ERc浓度比正常子宫肌层高3倍（P＜0.01），但PRc浓度无显著差异。所有检测组织中ERc和PRc的解离常数分别在10⁻¹⁰和10⁻⁹ M范围内，且在整个月经周期中无波动。结果表明，就整个月经周期中ERc和PRc浓度的变化模式以及PRc与ERc的比值（PRc/ERc）而言，子宫内膜、子宫肌层和输卵管属于一组，而宫颈与它们不同。值得注意的是，小肌瘤的PRc/ERc低于正常子宫肌层，提示可能与肌瘤的病理生长有关。
