Robelin J
J Lipid Res. 1981 Mar;22(3):452-7.
Changes in the cellularity of various adipose tissues in growing cattle were analyzed. Fifty male cattle were slaughtered between 15 and 65% of mature weight. The whole adipose mass, separated by dissection, was divided into three parts: subcutaneous, intermuscular, and internal adipose tissues. Lipid content, cell size and distribution, as well as cell number of these three parts were determined. Adipose cells became 15 times greater from 15 to 65% mature weight, whereas total adipose cell number increased only 1.8-fold. However, a significant hyperplasia occurred near 45% mature weight. These results suggested a cell size regulation by hyperplasia. Over the whole period studied (15-65% mature weight), hyperplasia was far higher in subcutaneous adipose tissue than in other tissues. This is discussed as related to the higher relative growth of this tissue. In each fatty tissue, two identical development periods were observed. Each of them began by an increase in small-sized cells (hyperplasia) followed by the filling of these cells (hypertrophy). These two periods were particularly clear in the case of subcutaneous tissue, in which the second hyperplasia occurred slightly later than in other fatty tissues. So, in all respects, subcutaneous fatty tissue appears to develop later than other tissues studied.
对生长中的牛不同脂肪组织的细胞构成变化进行了分析。五十头雄性牛在达到成熟体重的15%至65%之间时被屠宰。通过解剖分离出的整个脂肪块被分成三部分：皮下脂肪组织、肌间脂肪组织和内脏脂肪组织。测定了这三部分的脂质含量、细胞大小和分布以及细胞数量。从15%成熟体重到65%成熟体重，脂肪细胞体积增大了15倍，而脂肪细胞总数仅增加了1.8倍。然而，在接近45%成熟体重时出现了显著的细胞增生。这些结果表明细胞大小受细胞增生调节。在整个研究期间（15%至65%成熟体重），皮下脂肪组织中的细胞增生远高于其他组织。这被认为与该组织较高的相对生长有关。在每个脂肪组织中，观察到两个相同的发育阶段。每个阶段都始于小尺寸细胞数量的增加（细胞增生），随后是这些细胞的填充（细胞肥大）。这两个阶段在皮下组织中尤为明显，其中第二次细胞增生比其他脂肪组织稍晚出现。所以，在各方面，皮下脂肪组织似乎比其他研究组织发育得更晚。
