L-抗坏血酸2-硫酸酯对大鼠和豚鼠经各种处理诱导的脂肪肝和高脂血症的影响。

Effect of l-ascorbate 2-sulfate on fatty liver and hyperlipidemia induced by various treatments in rats and guinea pigs.

作者信息

Terada M, Wakusawa S, Watanabe Y, Kato M, Hayashi M, Hayashi E

出版信息

J Nutr Sci Vitaminol (Tokyo). 1980;26(6):521-34. doi: 10.3177/jnsv.26.521.

DOI:10.3177/jnsv.26.521

Abstract

Effects of L-ascorbate 2-sulfate (AAS) on fatty liver and hyperlipidemia induced by various treatments were studied in rats and guinea pigs. L-Ascorbic acid (AA) (50 or 175 mg/kg), a reference compound, lowered the lipid levels in the serum and/or liver in guinea pigs, while AA had little effect in rats. On the other hand, AAS (300 mg/kg) was effective in both animals. In rats, AAS lowered cholesterol and triglycerides in the serum from ethionine-treated animals and in the liver from orotic acid-supplemented animals. In guinea pigs, this compound lowered cholesterol and triglycerides in the serum from ethionine-treated animals, lipids in the liver from cholesterol-supplemented animals, and lipids in the serum and liver from scorbutic animals. AA markedly increased the content of AA in the organs in all experiments, while AAS had a slight effect. Thus, it is suggested that AAS exerts its hypolipidemic and lipotropic effects by the specific actions of AAS.

摘要

在大鼠和豚鼠中研究了L-抗坏血酸2-硫酸酯（AAS）对各种处理诱导的脂肪肝和高脂血症的影响。作为参考化合物的L-抗坏血酸（AA）（50或175mg/kg）可降低豚鼠血清和/或肝脏中的脂质水平，而AA对大鼠几乎没有影响。另一方面，AAS（300mg/kg）对两种动物均有效。在大鼠中，AAS可降低蛋氨酸处理动物血清中的胆固醇和甘油三酯以及乳清酸补充动物肝脏中的胆固醇和甘油三酯。在豚鼠中，该化合物可降低蛋氨酸处理动物血清中的胆固醇和甘油三酯、胆固醇补充动物肝脏中的脂质以及坏血病动物血清和肝脏中的脂质。在所有实验中，AA均显著增加器官中AA的含量，而AAS的作用轻微。因此，提示AAS通过其特异性作用发挥降血脂和促脂解作用。