Dabezies E J, Brunet M
Orthopedics. 1978 Jan-Feb;1(1):26-9.
Three hundred and nine patients having herniated nucleus pulposus syndrome were treated by chemonucleolysis with chymopapain. We analyzed the results of that treatment in the first 100 patients who had been followed up for two years. No significant allergic reactions, deaths, spinal cord injury or paralysis occurred. One patient had pulmonary embolus and another had a disk space infection. Diskitis did not occur. Of the 100 patients receiving chymopapain, 71% of the results were rated good to excellent; of those in a comparably followed-up group of 100 patients who underwent surgery, 63% of the results were rated good to excellent. The end result was achieved more quickly after chemonucleolysis and with less physiologic stress on the patient. The beneficial result was considered to be long lasting, and in our opinion, the quality of the end result was superior after chemonucleolysis.
309例患有髓核突出综合征的患者接受了木瓜凝乳蛋白酶化学髓核溶解术治疗。我们分析了前100例随访两年的患者的治疗结果。未发生明显的过敏反应、死亡、脊髓损伤或瘫痪。1例患者发生肺栓塞，另1例患者发生椎间盘间隙感染。未发生椎间盘炎。在接受木瓜凝乳蛋白酶治疗的100例患者中，71%的结果被评为良好至优秀；在接受手术的100例可比随访组患者中，63%的结果被评为良好至优秀。化学髓核溶解术后最终结果实现得更快，且对患者的生理压力更小。有益结果被认为是持久的，并且在我们看来，化学髓核溶解术后最终结果的质量更优。
