Vitorica J, Andrés A, Satrústegui J, Machado A
Neurochem Res. 1981 Feb;6(2):127-36. doi: 10.1007/BF00964829.
The patterns of brain enzymes linked to energy metabolism have been determined in rats aged between 3 and 21 months and compared to those of the developing brain as an estimate of the senescent energy capacity of this organ. During aging, pyruvate kinase increases, pointing towards an enhancement of the glucose-dependence of this organ. However, NAD-isocitrate dehydrogenase declines, suggesting a reduction of Krebs cycle activity in the aged rat brain. An increase in cytoplasmic NAD-malate dehydrogenase found during aging could provide an alternative mechanism of NAD recovery.
已测定3至21月龄大鼠中与能量代谢相关的脑酶模式，并将其与发育中大脑的酶模式进行比较，以此评估该器官的衰老能量容量。在衰老过程中，丙酮酸激酶增加，表明该器官对葡萄糖的依赖性增强。然而，NAD -异柠檬酸脱氢酶下降，这表明老年大鼠大脑中 Krebs 循环活性降低。衰老过程中发现的细胞质NAD -苹果酸脱氢酶增加可能提供了一种NAD回收的替代机制。
