Wree A, Kaever C, Birgel B, Schleicher A, Horvath E, Zilles K
Anatomisches Institut, Universität Würzburg, Federal Republic of Germany.
Histochemistry. 1991;95(6):591-603. doi: 10.1007/BF00266747.
The local cerebral glucose utilization (LCGU) was measured in 63 different cortical areas and nuclei of the telencephalon, diencephalon and rhombencephalon of young adult (3 to 4-month-old) rats and of 27-month-old Wistar rats, in which learning impairments had been proven by a water maze test. The LCGU was determined by [14C]2-deoxyglucose autoradiography. In the old rats the mean LCGU of all brain regions was significantly reduced by about 10% compared with the young control group; the mean LCGU was 74.2 mumol glucose/(100 g x min) in the young and 66.7 in the old rats. Different degrees of LCGU decrease were found in the different regions. Most of the brain regions with significantly reduced LCGU values in the aged, learning impaired rats were associated with auditory and visual functions, the dopaminergic system, and structures known to be involved in learning and memory processes. Therefore, the regional pattern of LCGU reduction found in the aged, learning impaired rats did not resemble any known pattern found after lesions of a single transmitter system or systemic administration of transmitter agonists or antagonists.
在年轻成年（3至4个月大）大鼠以及27个月大的Wistar大鼠（通过水迷宫试验已证实存在学习障碍）的端脑、间脑和后脑的63个不同皮质区域和神经核中，测量了局部脑葡萄糖利用率（LCGU）。通过[14C]2-脱氧葡萄糖放射自显影法测定LCGU。与年轻对照组相比，老年大鼠所有脑区的平均LCGU显著降低约10%；年轻大鼠的平均LCGU为74.2微摩尔葡萄糖/（100克×分钟），老年大鼠为66.7。在不同区域发现了不同程度的LCGU降低。在老年、学习受损大鼠中，LCGU值显著降低的大多数脑区与听觉和视觉功能、多巴胺能系统以及已知参与学习和记忆过程的结构有关。因此，在老年、学习受损大鼠中发现的LCGU降低的区域模式与单一递质系统损伤或全身给予递质激动剂或拮抗剂后发现的任何已知模式均不相似。
