Davidson G P, Koheil A, Forstner G G
Pediatr Res. 1978 Oct;12(10):967-70. doi: 10.1203/00006450-197810000-00003.
Total serum amylase was determined in 83 patients with cystic fibrosis (CF) (14 of whom had no steatorrhea), 21 control patients, and 6 patients with Shwachman's syndrome. Patients with CF who had steatorrhea and therefore lacked pancreatic function had the same serum levels pre- and postprandially as the control subjects, whereas patients without steatorrhea and, therefore, with evidence of pancreatic function, had significantly higher levels. The patients with Shwachman's syndrome had significantly lower total serum amylase than the three other patient groups. Only the patients with Shwachman's syndrome demonstrated a significant postprandial rise in activity. Only the salivary isoenzyme was detected in patients with Shwachman's syndrome or CF and apparently absent pancreatic function, whereas CF patients without steatorrhea had both salivary and pancreatic isoenzymes. These results demonstrate that patients with CF have an increase in circulating salivary amylase isoenzyme whereas patients with Shwachman's syndrome do not. The increase probably reflects an autonomic hyperstimulation of salivary secretion which is primary to CF, and unrelated to the state of pancreatic activity.
对83例囊性纤维化（CF）患者（其中14例无脂肪泻）、21例对照患者和6例施瓦赫曼综合征患者测定了血清总淀粉酶。有脂肪泻且因此缺乏胰腺功能的CF患者，其血清水平在餐前和餐后与对照受试者相同，而无脂肪泻且因此有胰腺功能证据的患者，其血清水平显著更高。施瓦赫曼综合征患者的血清总淀粉酶显著低于其他三组患者。只有施瓦赫曼综合征患者餐后活性有显著升高。在施瓦赫曼综合征患者或CF且明显无胰腺功能的患者中仅检测到唾液同工酶，而无脂肪泻的CF患者既有唾液同工酶又有胰腺同工酶。这些结果表明，CF患者循环中的唾液淀粉酶同工酶增加，而施瓦赫曼综合征患者则没有。这种增加可能反映了唾液分泌的自主神经高刺激，这是CF的原发性表现，与胰腺活动状态无关。
