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囊性纤维化患者血清α淀粉酶的活性

Activity of serum alpha-amylases in cystic fibrosis.

作者信息

Kenny D, Cooke A, Tempany E, McGeeney K F

出版信息

Clin Chim Acta. 1978 Nov 1;89(3):429-33. doi: 10.1016/0009-8981(78)90406-0.

DOI:10.1016/0009-8981(78)90406-0
PMID:309368
Abstract

A new method which uses a differential inhibitor to measure pancreatic and salivary type alpha-amylases (EC 3.2.1.1) was applied to serum samples from 46 cystic fibrosis (CF) patients (age range 4-14 years) and 50 controls of the same age group. The levels of pancreatic type amylase were lower in the CF patients (median 26.5 I.U./1) than the controls (median 81.5) (P less than 0.001). The results for salivary-type enzyme, however, did not support the previously reported finding of higher than usual levels in CF patients. This discrepancy is probably due to differences in analytical methods. It is felt that this procedure will be of value in the investigation of patients for cystic fibrosis and other pancreatic disorders.

摘要

一种使用差分抑制剂来测量胰腺型和唾液型α淀粉酶(EC 3.2.1.1)的新方法被应用于46例囊性纤维化(CF)患者(年龄范围4至14岁)和50例同年龄组对照的血清样本。CF患者的胰腺型淀粉酶水平(中位数26.5国际单位/升)低于对照组(中位数81.5)(P<0.001)。然而,唾液型酶的结果并不支持先前报道的CF患者中该酶水平高于正常的发现。这种差异可能是由于分析方法的不同。人们认为该方法在囊性纤维化和其他胰腺疾病患者的调查中将具有价值。

相似文献

1
Activity of serum alpha-amylases in cystic fibrosis.囊性纤维化患者血清α淀粉酶的活性
Clin Chim Acta. 1978 Nov 1;89(3):429-33. doi: 10.1016/0009-8981(78)90406-0.
2
Salivary amylase in cystic fibrosis: a marker of disordered autonomic function.囊性纤维化中的唾液淀粉酶:自主神经功能紊乱的一个标志物。
Pediatr Res. 1978 Oct;12(10):967-70. doi: 10.1203/00006450-197810000-00003.
3
[Isoenzymes of alpha-amylase in the sera of patients with cystic fibrosis].
Z Klin Chem Klin Biochem. 1974 May;12(5):214-6.
4
Use of serum amylase isoenzymes in evaluation of pancreatic function.血清淀粉酶同工酶在胰腺功能评估中的应用。
Pediatrics. 1974 Aug;54(2):229-35.
5
Differences between cystic fibrosis and normal saliva alpha-amylase as a function of age and sex.
Pediatr Res. 1978 Aug;12(8):868-72. doi: 10.1203/00006450-197808000-00013.
6
Plasma pancreatic and salivary-type amylase and immunoreactive trypsin concentrations: variations with age and reference ranges for children.血浆胰腺和唾液型淀粉酶及免疫反应性胰蛋白酶浓度:儿童随年龄的变化及参考范围
Clin Chim Acta. 1980 Jul 1;104(3):265-73. doi: 10.1016/0009-8981(80)90384-8.
7
Three methods compared for determination of pancreatic and salivary amylase activity in serum of cystic fibrosis patients.
Clin Chem. 1986 Feb;32(2):296-300.
8
Amylase polymorphism: studies of sera and duodenal aspirates in normal individuals and in cystic fibrosis.淀粉酶多态性:正常个体及囊性纤维化患者血清与十二指肠抽吸物的研究
Am J Hum Genet. 1976 Jul;28(4):378-89.
9
[Amylasemia, heterogeneity of serum amylase and activity of the sweat amylolytic enzyme in members of families afflicted with mucoviscidosis].[黏多糖病患者家族成员的淀粉血症、血清淀粉酶的异质性及汗液淀粉分解酶活性]
Cesk Pediatr. 1970 Feb;25(2):78-81.
10
Serum amylase isoenzymes in cystic fibrosis patients. Evidence for a generalized defect in exocrine gland secretory regulation.
Pediatr Res. 1980 Nov;14(11):1168-72. doi: 10.1203/00006450-198011000-00004.

引用本文的文献

1
Serum immuno reactive trypsin and pancreatic isoamylase in older patients with cystic fibrosis.老年囊性纤维化患者的血清免疫反应性胰蛋白酶和胰腺异淀粉酶
Ir J Med Sci. 1981 Nov;150(11):325-8. doi: 10.1007/BF02938267.
2
Comparison of the diagnostic value of serum pancreatic isoamylase and immunoreactive trypsin measurement in patients with cystic fibrosis.囊性纤维化患者血清胰淀粉酶同工酶与免疫反应性胰蛋白酶检测诊断价值的比较。
J Clin Pathol. 1982 May;35(5):547-9. doi: 10.1136/jcp.35.5.547.