Herbert W N, Tyson J, Jimenez J M
Obstet Gynecol. 1981 Apr;57(4):426-30.
The frequency and severity of respiratory distress syndrome (RDS) were evaluated in 69 infants whose amniotic fluid lecithin: sphingomyelin (L:S) ratio was less than 2. Amniotic fluid was obtained at the time of either nonelective or elective cesarean section in 58 cases. An additional 11 patients were delivered within 48 hours after amniocentesis. Gestational ages ranged from 27 to 41 weeks. Few women had been in labor, none had ruptured membranes for more than 12 hours, and all but 3 were delivered by cesarean section. A variety of pregnancy complications were represented. All 14 infants with an L:S ratio less than 0.5 developed RDS, and 10 died. Of 19 infants with an L:S ratio of 0.5 to 0.99, 8 developed RDS; 3 of the 8 died and another 3 required ventilatory support. Of 36 infants whose L:S ratio exceeded 1.0, only 1 developed RDS. No infant who had an L:S ratio greater than 0.8 died of RDS, and RDS was absent in infants with L:S ratio as low as 0.6. These findings could not be attributed to intraassay or interassay variability or to laboratory methodology. The importance of individual laboratory evaluation of L:S values in relation to respiratory outcome is emphasized.
对69例羊水卵磷脂：鞘磷脂（L:S）比值小于2的婴儿的呼吸窘迫综合征（RDS）的发生率和严重程度进行了评估。58例在非选择性或选择性剖宫产时获取羊水。另外11例患者在羊膜穿刺术后48小时内分娩。孕周为27至41周。很少有女性临产，没有产妇胎膜破裂超过12小时，除3例以外均行剖宫产分娩。存在多种妊娠并发症。L:S比值小于0.5的14例婴儿均发生RDS，其中10例死亡。L:S比值为0.5至0.99的19例婴儿中，8例发生RDS；8例中的3例死亡，另外3例需要通气支持。L:S比值超过1.0的36例婴儿中，仅1例发生RDS。L:S比值大于0.8的婴儿无1例死于RDS, L:S比值低至0.6 的婴儿未发生RDS。这些发现不能归因于批内或批间变异或实验室方法。强调了针对呼吸结局对L:S值进行个体实验室评估的重要性。
