Imperato-McGinley J, Peterson R E, Dawood M Y, Zullo M, Kramer E, Saxena B B, Arthur A, Huang T
Obstet Gynecol. 1981 Apr;57(4):525-31.
The authors report the case of a 23-year-old woman with a virilizing lipoid cell tumor of the ovary. The patient developed precocious puberty at age 4 and from age 5 to 10 years was treated weekly with intramuscular medroxyprogesterone acetate. She began to menstruate spontaneously at age 13, but developed hirsutism, acne, and irregular menses at age 15 followed by secondary amenorrhea at age 20. Steroid analyses demonstrated elevated peripheral plasma levels of testosterone, dihydrotestosterone, androstenedione, 17 alpha-hydroxyprogesterone, progesterone, desoxycorticosterone, estrone, and estradiol. Catheterization of the adrenal and ovarian veins revealed increased secretion of testosterone, dehydroepiandrosterone, androstenedione, 17 alpha-hydroxyprogesterone, progesterone, desoxycortcosterone, and corticosterone, 11-desoxycortisol, cortisol, estrone, and estradiol from the right ovarian vein. At surgery a right ovarian lipoid cell tumor was removed. Incubation studies with the tumor tissue confirmed the presence of gonadal and adrenocortical steroids. The tissue also contained high-affinity human chorionic gonadotropin-luteinizing hormone binding sites with normal binding affinity.
作者报告了一例患有卵巢男性化类脂质细胞瘤的23岁女性病例。该患者4岁时出现性早熟，5至10岁期间每周接受醋酸甲羟孕酮肌肉注射治疗。她13岁开始自然月经，但15岁时出现多毛、痤疮和月经不规律，随后20岁时继发闭经。类固醇分析显示外周血中睾酮、双氢睾酮、雄烯二酮、17α-羟孕酮、孕酮、脱氧皮质酮、雌酮和雌二醇水平升高。肾上腺和卵巢静脉插管显示右卵巢静脉中睾酮、脱氢表雄酮、雄烯二酮、17α-羟孕酮、孕酮、脱氧皮质酮、皮质酮、11-脱氧皮质醇、皮质醇、雌酮和雌二醇的分泌增加。手术切除了右侧卵巢类脂质细胞瘤。对肿瘤组织进行的孵育研究证实了性腺和肾上腺皮质类固醇的存在。该组织还含有具有正常结合亲和力的高亲和力人绒毛膜促性腺激素-促黄体生成素结合位点。
