Shenker Y, Malozowski S N, Ayers J, Grekin R J, Barkan A L
Endocrinology Section, William S. Middleton Memorial Veterans Administration Hospital, Madison, Wisconsin.
Obstet Gynecol. 1989 Sep;74(3 Pt 2):502-6.
A 78-year-old woman had a 3-year history of severe virilization caused by a lipoid cell ovarian tumor localized by pelvic ultrasound examination and NP-59 scan. Steroid secretion was evaluated by the following: 1) peripheral plasma levels before and after hormonal stimulation with ACTH or hCG, 2) venous catheterization and measurement of steroid levels in the left and right ovarian veins during surgery, 3) measurements of enzymatic activities in the tumor tissue compared with those in normal ovarian tissue, and 4) steroid secretion studies in vitro of the tumor tissue, surrounding tissue, and contralateral ovarian tissue. The tumor tissue secreted both delta 5 and delta 4 androgens, including dehydroepiandrosterone sulfate. Dehydroepiandrosterone sulfate was also secreted by the surrounding and contralateral ovarian tissue.
一名78岁女性因盆腔超声检查和NP - 59扫描发现的类脂质细胞瘤，有3年严重男性化病史。通过以下方式评估类固醇分泌情况：1）促肾上腺皮质激素（ACTH）或人绒毛膜促性腺激素（hCG）激素刺激前后的外周血浆水平；2）手术期间经静脉导管插入术测量左、右卵巢静脉中的类固醇水平；3）将肿瘤组织中的酶活性与正常卵巢组织中的酶活性进行比较；4）对肿瘤组织、周围组织和对侧卵巢组织进行体外类固醇分泌研究。肿瘤组织分泌δ5和δ4雄激素，包括硫酸脱氢表雄酮。周围和对侧卵巢组织也分泌硫酸脱氢表雄酮。
