Newbrun E
Pediatrics. 1978 Nov;62(5):733-7.
Fluoride supplements are effective in preventing dental caries if conscientiously taken on a daily basis from birth until at least 12 to 14 years of age. The optimal dose depends on the child's age and the existing fluoride concentration in the water supply. A dosage schedule is recommended that decreases the dose of fluoride in infancy and that is inversely related to the concentration of fluoride in the drinking water.
如果从出生到至少12至14岁期间每天认真服用氟化物补充剂，那么它对预防龋齿是有效的。最佳剂量取决于孩子的年龄以及供水系统中现有的氟化物浓度。建议采用一种剂量方案，该方案在婴儿期减少氟化物剂量，并且与饮用水中的氟化物浓度成反比。
