Guggenbichler J
Padiatr Padol. 1981;16(2):273-86.
There are considerable differences in the oral absorption of antibiotics. Different groups of drugs and different galenic preparations of the same compound show vast differences in their bioavailability. This is not without therapeutic consequences. These differences depend on water and lipid solubility of drugs, the dissociation constant and polarity of the side chains. The first part describes methods of determination of serum and urine concentrations. The determination of pharmakokinetic parameters allows an assessment of the bioavailability, however there are pitfalls, by overemphasizing a single parameter in the calculation. We are able to demonstrate differences in the resorption of various penicillin salts, and of different aminopenicillins in dependence of their side chains with differences in their polarity. It should be stressed, that only the calculation and consideration of all pharmakokinetic parameters together allows a fair assessment of the quality of absorption of an antibiotic.
抗生素的口服吸收存在相当大的差异。不同类别的药物以及同一化合物的不同剂型在生物利用度上表现出巨大差异。这并非没有治疗上的影响。这些差异取决于药物的水溶性和脂溶性、解离常数以及侧链的极性。第一部分描述了血清和尿液浓度的测定方法。药代动力学参数的测定有助于评估生物利用度，然而在计算中过度强调单个参数会存在一些陷阱。我们能够证明各种青霉素盐以及不同氨基青霉素的吸收差异取决于它们侧链的极性差异。应当强调的是，只有综合计算和考虑所有药代动力学参数，才能对一种抗生素的吸收质量进行合理评估。
