Pearson H A
Pediatrics. 1978 Nov;62(5 Pt 2 Suppl):926-9.
Aspirin, even in small doses, has a profound and relatively long-lasting effect on platelet function and hemostasis. This usually produces few clinical problems. However, if a patient has an underlying hemostatic defect, undergoes surgery or sustains an injury, or is a newborn, severe hemorrhage is a potential risk. Aspirin is contraindicated in these clinical contexts. In contrast, acetaminophen has no effect on the hemostatic mechanism unless massive overdose results in hepatic necrosis with depression of synthesis of coagulation factors. Acetaminophen can be used when indicated in clinical situations where the use of aspirin may be potentially dangerous.
阿司匹林即使小剂量使用，也会对血小板功能和止血产生深远且相对持久的影响。这通常不会引发多少临床问题。然而，如果患者存在潜在的止血缺陷、接受手术或遭受损伤，或者是新生儿，严重出血就会成为一个潜在风险。在这些临床情况下，阿司匹林是禁忌的。相比之下，对乙酰氨基酚除非大量过量服用导致肝坏死并伴有凝血因子合成受抑，否则对止血机制没有影响。在使用阿司匹林可能存在潜在危险的临床情形中，如有指征时可以使用对乙酰氨基酚。
