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持续性非卧床腹膜透析的代谢效应

Metabolic effects of continuous ambulatory peritoneal dialysis.

作者信息

Lindholm B, Alvestrand A, Fürst P, Karlander S G, Norbeck H E, Ahlberg M, Tranaeus A, Bergström J

出版信息

Proc Eur Dial Transplant Assoc. 1980;17:283-90.

PMID:7243780
Abstract

Prospective studies concerning protein, carbohydrate, and lipid metabolism were performed in 19 CAPD patients. After 2-4 months on CAPD the mean nitrogen balance was positive (3.14 +/- 1.98 g N/day) and was correlated with protein and energy intake as well as with the increase in body weight. Plasma free amino acid concentrations were normal, but the tyrosine/phenylalanine ratio was decreased compared with healthy subjects. In spite of the excessive glucose load, there was no further deterioration in glucose tolerance. Serum concentrations of TG and CHOL were increased due to a rise of VLDL-TG and VLDL-CHOL.

摘要

对19例持续性非卧床腹膜透析(CAPD)患者进行了关于蛋白质、碳水化合物和脂质代谢的前瞻性研究。在进行CAPD治疗2 - 4个月后,平均氮平衡为正值(3.14±1.98克氮/天),且与蛋白质和能量摄入以及体重增加相关。血浆游离氨基酸浓度正常,但与健康受试者相比,酪氨酸/苯丙氨酸比值降低。尽管有过量的葡萄糖负荷,但糖耐量并未进一步恶化。由于极低密度脂蛋白甘油三酯(VLDL - TG)和极低密度脂蛋白胆固醇(VLDL - CHOL)升高,甘油三酯(TG)和胆固醇(CHOL)的血清浓度增加。

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