1α（OH）D3 导致非透析尿毒症患者肾功能恶化，且这并非由高钙血症所致。
Deterioration of renal function in non-dialytic uraemics caused by 1 alpha (OH)D3 which was not attributable to hypercalcaemia.
作者信息
Yoshiyama N, Akiba T, Matsui N, Iwamoto H, Ogura M, Nakagawa S, Takeuchi J
出版信息
Proc Eur Dial Transplant Assoc. 1980;17:569-74.
Ten patients with renal failure not on dialysis were subjected to our study to evaluate the effect of 1 alpha (OH)D3 on calcium metabolism and its influence on renal function. The results suggest the possibility that 1 alpha (OH)D3 might be effective in bone disease due to secondary hyperparathyroidism. On the other hand, 1 alpha (OH)D3 depressed creatinine clearance without any increase of Ca, Ca x P product or PRA. 1 alpha (OH)D3 is to be prescribed to patients not on dialysis only with careful attention to the dosage and the duration, and frequent observation of renal function is necessary.
10例未接受透析的肾衰竭患者参与了我们的研究，以评估1α（OH）D3对钙代谢的影响及其对肾功能的作用。结果提示，1α（OH）D3可能对继发性甲状旁腺功能亢进所致的骨病有效。另一方面，1α（OH）D3降低了肌酐清除率，而血钙、钙磷乘积或血浆肾素活性均未升高。仅在密切关注剂量和疗程并频繁监测肾功能的情况下，才可给未接受透析的患者开具1α（OH）D3。
Zotero 插件