Hoffman P L, Ritzmann R F, Tabakoff B
Pharmacol Biochem Behav. 1980;13 Suppl 1:279-84. doi: 10.1016/s0091-3057(80)80042-6.
The neurohypophyseal hormone, arginine vasopressin (AVP), was previously shown to prolong the duration of ethanol tolerance in mice. Since drug tolerance and certain memory-related processes are examples of CNS adaptation, these phenomena have been proposed to share underlying mechanisms. We investigated the effects on ethanol tolerance of two other neurohypophyseal peptides, both of which modulate memory consolidation or retrieval of information. (Des-9-glycinamide, 8-lysine) vasopressin (DGLVP), like AVP, maintained ethanol tolerance in C57Bl mice, while cyclo(Leu-Gly) (cLG), at an equimolar dose, was ineffective. Thus, various neurohypophyseal peptides may differentially influence CNS adaptive phenomena. Direct peptide effects on ethanol-induced hypothermia and "sleep time," the parameters used to evaluate ethanol tolerance, were also determined. AVP per se caused hypothermia in mice, but neither AVP nor cLG affected ethanol-induced hypothermia. Both peptides, however, increased "sleep time" after acute ethanol administration. Although these direct peptide-ethanol interactions do not account for the observed peptide effects on tolerance, the findings emphasize the importance of using several parameters to assess ethanol tolerance.
神经垂体激素精氨酸加压素（AVP）此前已被证明可延长小鼠对乙醇的耐受时间。由于药物耐受性和某些与记忆相关的过程是中枢神经系统适应性的例子，因此有人提出这些现象具有共同的潜在机制。我们研究了另外两种神经垂体肽对乙醇耐受性的影响，这两种肽都能调节记忆巩固或信息检索。（去 -9-甘氨酰胺，8-赖氨酸）加压素（DGLVP）与AVP一样，能维持C57Bl小鼠对乙醇的耐受性，而等摩尔剂量的环（亮氨酸 - 甘氨酸）（cLG）则无效。因此，各种神经垂体肽可能对中枢神经系统适应性现象有不同的影响。还确定了肽对乙醇诱导的体温过低和“睡眠时间”（用于评估乙醇耐受性的参数）的直接影响。AVP本身会导致小鼠体温过低，但AVP和cLG均不影响乙醇诱导的体温过低。然而，两种肽在急性给予乙醇后都会增加“睡眠时间”。尽管这些肽与乙醇的直接相互作用并不能解释所观察到的肽对耐受性的影响，但这些发现强调了使用多个参数来评估乙醇耐受性的重要性。
