Hoffman P L, Tabakoff B
Drug Alcohol Depend. 1979 May-Jul;4(3-4):249-53. doi: 10.1016/0376-8716(79)90006-1.
Chronic exposure of mice to ethanol leads to the development of functional tolerance to the hypothermic and sedative effects of this drug. Treatment of the animals with the mammalian antidiuretic hormone, arginine vasopressin, results in a prolonged duration of such tolerance, in comparison to animals exposed to ethanol but not to the hormone. Another neurohypophyseal hormone, oxytocin, at an equimolar dose, is ineffective in maintaining tolerance. The centrally mediated effects of arginine vasopressin on memory processes may be related to the hormone-induced prolongation of ethanol tolerance.
小鼠长期接触乙醇会导致对该药物的体温过低和镇静作用产生功能性耐受。与仅接触乙醇而未接触该激素的动物相比，用哺乳动物抗利尿激素精氨酸加压素治疗这些动物会导致这种耐受持续时间延长。另一种神经垂体激素——催产素，在等摩尔剂量下，对维持耐受无效。精氨酸加压素对记忆过程的中枢介导作用可能与该激素诱导的乙醇耐受延长有关。
