Luzi P, Lungarella G, Leoncini L, Miracco C
Quad Sclavo Diagn. 1980 Mar;16(1):30-9.
22 liver biopsies from patients affected by brucellosis (Brucella melitensis) have been studied as far as granuloma formation is concerned. The first phase of granulomatous lesion seems to be the presence of monocytes within the hepatic sinusoids. Then we can observe small histiocytic granuloma and finally a "mature" (Adams [1]) granuloma, i.e. an organized collection of mature mononuclear phagocytes without necrosis, but sometimes with giant cells.
