Thiamine protection of murine L1210 leukemia cells against mechlorethamine cytotoxicity and its relation to the choline uptake system.
作者信息
Naujokaitis S A
出版信息
Res Commun Chem Pathol Pharmacol. 1981 May;32(2):317-27.
PMID:7244366
Abstract
Thiamine is an inhibitor of choline transport by murine L1210 leukemia cells and a protector of these cells from growth inhibition by mechlorethamine in vitro. Combination chemotherapy of tumor bearing mice with thiamine and mechlorethamine increased the mechlorethamine dosage required for a 50 to 60 percent increase in survival time but did not improve survival over that obtained with mechlorethamine alone.
摘要
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