• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Determination of meperidine blood to plasma concentration ratio (lambda) - effect of temperature and pH.

作者信息

Jackson A J

出版信息

Res Commun Chem Pathol Pharmacol. 1981 May;32(2):365-8.

PMID:7244369
Abstract

The blood to plasma concentration ratio (lambda) for meperidine was found to be temperature and pH dependent but independent of concentration. lambda values at room temperature were significantly lower than those at 37 degrees C (p less than .01). Decreasing the blood pH within the range 7.2 to 6.9 resulted in a significant decrease in lambda (p less than .01).

摘要

相似文献

1
Determination of meperidine blood to plasma concentration ratio (lambda) - effect of temperature and pH.
Res Commun Chem Pathol Pharmacol. 1981 May;32(2):365-8.
2
Meperidine and skin surface warming additively reduce the shivering threshold: a volunteer study.哌替啶与皮肤表面升温可叠加降低寒战阈值：一项志愿者研究。
Crit Care. 2007;11(1):R29. doi: 10.1186/cc5709.
3
Distribution of methotrexate in human blood in vitro: independence of temperature, pH and drug concentration.甲氨蝶呤在人血液中的体外分布：温度、pH值和药物浓度的独立性
Int J Clin Pharmacol Ther Toxicol. 1987 Aug;25(8):417-20.
4
Pharmacokinetics and local responses to submucosal meperidine compared with other routes of administration.
Pediatr Dent. 1994 May-Jun;16(3):190-2.
5
Pethidine binding in plasma: effects of methodological variables.血浆中哌替啶的结合：方法学变量的影响。
Br J Clin Pharmacol. 1984 Apr;17(4):411-5. doi: 10.1111/j.1365-2125.1984.tb02365.x.
6
Use of a new fluorescent probe, seminaphthofluorescein-calcein, for determination of intracellular pH by simultaneous dual-emission imaging laser scanning confocal microscopy.使用一种新型荧光探针半萘荧光素-钙黄绿素，通过同步双发射成像激光扫描共聚焦显微镜测定细胞内pH值。
J Cell Physiol. 1995 Jul;164(1):9-16. doi: 10.1002/jcp.1041640103.
7
Influence of pH on stored human platelets.pH对储存人血小板的影响。
Transfusion. 2007 Oct;47(10):1889-95. doi: 10.1111/j.1537-2995.2007.01412.x.
8
Urinary excretion of meperidine and normeperidine in man upon acute and chronic exposure to high altitude.
Methods Find Exp Clin Pharmacol. 1996 Jan-Feb;18(1):49-53.
9
Headspace gas chromatographic determination of ethanol: the use of factorial design to study effects of blood storage and headspace conditions on ethanol stability and acetaldehyde formation in whole blood and plasma.顶空气相色谱法测定乙醇：运用析因设计研究血液储存和顶空条件对全血及血浆中乙醇稳定性和乙醛生成的影响
Forensic Sci Int. 2006 Sep 12;161(2-3):151-7. doi: 10.1016/j.forsciint.2006.03.034. Epub 2006 Jul 14.
10
Renal tubular secretion of meperidine by the fetal lamb.胎羊肾小管对哌替啶的分泌
J Pharmacol Exp Ther. 1980 May;213(2):346-9.

引用本文的文献

1
Clinical pharmacokinetics of pethidine: 1982.哌替啶的临床药代动力学：1982年。
Clin Pharmacokinet. 1982 Sep-Oct;7(5):421-33. doi: 10.2165/00003088-198207050-00003.
2
Pethidine binding in plasma: effects of methodological variables.血浆中哌替啶的结合：方法学变量的影响。
Br J Clin Pharmacol. 1984 Apr;17(4):411-5. doi: 10.1111/j.1365-2125.1984.tb02365.x.