抗精神病药物所致快感缺乏测量中的反应伪迹。

Response artifact in the measurement of neuroleptic-induced anhedonia.

作者信息

Ettenberg A, Koob G F, Bloom F E

出版信息

Science. 1981 Jul 17;213(4505):357-9. doi: 10.1126/science.7244622.

Abstract

Systemic administration of the neuroleptic drug alpha-flupenthixol attenuated lever-pressing behavior in rats responding for rewarding brain stimulation. The magnitude of this attenuation was dose-dependent and resembled the effects of reward reduction and termination. However, when the operant response requirements of the same rats were changed to nose poking, identical drug treatments produced relatively little attenuation in performance. These data do not support the belief that neuroleptics produce a general state of anhedonia. Rather, the apparent suppression of reinforced behaviors depends at least in part on the kinetic requirements of the response.

摘要

对大鼠进行脑刺激奖赏时，给予抗精神病药物α-氟奋乃静的全身给药减弱了大鼠的杠杆按压行为。这种减弱的程度呈剂量依赖性，类似于奖赏减少和终止的效果。然而，当将同一只大鼠的操作性反应要求改为鼻触时，相同的药物处理对行为表现的减弱作用相对较小。这些数据并不支持抗精神病药物会产生一种普遍的快感缺失状态这一观点。相反，强化行为的明显抑制至少部分取决于反应的动力学要求。