Gross M D, Valk T W, Swanson D P, Thrall J H, Grekin R J, Beirewaltes W H
Semin Nucl Med. 1981 Apr;11(2):128-48. doi: 10.1016/s0001-2998(81)80042-6.
Adrenal scintigraphy is a unique nuclear medicine procedure that provides noninvasive, functional information concerning the status of the adrenal cortex. The uptake of iodocholesterol, in addition to localizing adrenal cortical abnormalities, can be manipulate to focus on adrenal cortical dysfunction in either the aldosterone, cortisol, or androgenproducing portions of the adrenal cortex. The uptake of iodocholesterol correlates significantly with the abnormal secretion of cortisol in Cushing's syndrome, aldosterone in the model of adrenal zona glomerulosa function, and adrenal androgen secretion in hyperandorgenism. For these reasons, adrenal scintigraphy is an important diagnostic modality in the evaluation of adrenal cortical function.
肾上腺闪烁显像是一种独特的核医学检查方法，可提供有关肾上腺皮质状态的非侵入性功能信息。除了定位肾上腺皮质异常外，碘胆固醇的摄取还可用于聚焦肾上腺皮质醛固酮、皮质醇或雄激素分泌部分的功能障碍。在库欣综合征中，碘胆固醇的摄取与皮质醇异常分泌显著相关；在肾上腺球状带功能模型中，与醛固酮异常分泌相关；在高雄激素血症中，与肾上腺雄激素分泌相关。基于这些原因，肾上腺闪烁显像在评估肾上腺皮质功能方面是一种重要的诊断方式。
