金对DNA的光致敏作用。
Photosnesitization of DNA by gold.
作者信息
Wilkins R J
出版信息
Nucleic Acids Res. 1978 Oct;5(10):3731-42. doi: 10.1093/nar/5.10.3731.
Abstract
Au (III) reacts with DNA at pH 5.6 to form a complex which is sensitive to mid-UV radiation. Cyclobutane pyrimidine dimers are produced at some 15 to 30 times the rate that they are in untreated DNA. The mechanism of photosensitization appears to involve energy absorption by Au-urine and Au-cytosine adducts which can then transfer energy to thymine residues. There is no evidence for a "heavy atom" effect which enables metals such as Ag to mix excited states of DNA and to increase the quantum yields of some photoproducts. The use of mid-UV radiation as a probe for investigating the interaction between DNA and drugs such as sodium aurothiomalate is discussed.
摘要
金（III）在pH 5.6时与DNA反应形成一种对中紫外辐射敏感的复合物。环丁烷嘧啶二聚体的产生速率约为未处理DNA中的15至30倍。光致敏机制似乎涉及金-尿嘧啶和金-胞嘧啶加合物吸收能量，然后将能量转移到胸腺嘧啶残基。没有证据表明存在“重原子”效应，这种效应能使银等金属混合DNA的激发态并提高某些光产物的量子产率。本文讨论了使用中紫外辐射作为探针来研究DNA与金硫代苹果酸钠等药物之间的相互作用。
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