核苷酸的两性离子特性：在核酸进化中的可能意义。
Zwitterionic character of nucleotides: possible significance in the evolution of nucleic acids.
作者信息
Sundaralingam M, Prusiner P
出版信息
Nucleic Acids Res. 1978 Nov;5(11):4375-83. doi: 10.1093/nar/5.11.4375.
Abstract
X-ray crystallography has shown that the free acids of adenosine 5'- and 3'-monophosphates and of cytidine 5'- and 3'-monophosphates exist as zwiterions in the solid state with protonation of the adenine base at the N(1) site and of the cytosine base at the corresponding site N(3) and the phosphate group negatively charged. In this paper, evidence is presented for the zwitterionic character of the free acids of the monomeric nucleotides guanosine 5'-monophosphate and inosine 5'-monophosphate with protonation of the base at the N(7) site of the imidazole moiety.
摘要
X射线晶体学表明，腺苷5'-单磷酸和3'-单磷酸以及胞苷5'-单磷酸和3'-单磷酸的游离酸在固态下以两性离子形式存在，腺嘌呤碱基在N(1)位点质子化，胞嘧啶碱基在相应的N(3)位点质子化，磷酸基团带负电荷。本文提供了证据，证明鸟苷5'-单磷酸和肌苷5'-单磷酸的游离酸具有两性离子特性，其碱基在咪唑部分的N(7)位点质子化。
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本文引用的文献
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Structure of the monoclinic form of cytidylic acid b.
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Stereochemistry of nucleic acids and their constituents. XVII. Crystal and molecular structure of deoxycytidine 5'-phosphate monohydrate. A possible puckering for the furanoside ring in B-deoxyribonucleic acid.
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J Am Chem Soc. 1977 Feb 2;99(3):714-8. doi: 10.1021/ja00445a009.
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