Susheela A K, Sharma Y D
Toxicol Eur Res. 1981 Mar;3(2):105-7.
Rabbits in two groups were given different doses of sodium fluoride i.e. low dose (10 mg NaF/kg body weight) and high dose (50 mg NaF/kg body weight). Blood was drawn from both groups on certain specific days after fluoride administration. The two different doses of sodium fluoride gave different response with regards to the fibrinogen levels in blood plasma. It is suggested that administration of low doses of sodium fluoride, induce new bone formation enhancing fibrinogen levels. But in high doses of sodium fluoride, moderate tissue damage results in high levels of plasma fibrinogen.
将两组兔子给予不同剂量的氟化钠，即低剂量（10毫克氟化钠/千克体重）和高剂量（50毫克氟化钠/千克体重）。在给予氟化物后的特定日子从两组中抽取血液。两种不同剂量的氟化钠对血浆中纤维蛋白原水平产生了不同的反应。有人认为，低剂量氟化钠的给药会诱导新骨形成，提高纤维蛋白原水平。但在高剂量氟化钠的情况下，中度组织损伤会导致血浆纤维蛋白原水平升高。
