Das T K, Susheela A K
Department of Anatomy, All India Institute of Medical Sciences, New Delhi.
Environ Res. 1993 Jul;62(1):14-8. doi: 10.1006/enrs.1993.1084.
The present study was undertaken to determine the effect of chronic fluoride toxicity on calcium metabolism. Rabbits (n = 10) were orally administered an aqueous solution of 10 mg NaF/kg body wt daily for 18 months. Equal numbers (n = 10) of age-, sex- and weight-matched rabbits kept under identical laboratory conditions, but not treated, with NaF solution, served as control. The fasting plasma calcium concentrations of fluoride-treated rabbits were significantly lower (P < 0.001) than those of control animals. In contrast to the decrease in plasma calcium level, and increase in intestinal radioactive calcium (45Ca) absorption was observed (P < 0.001) in all fluoride-treated animals. However, urinary calcium excretion levels were found to be reduced (P = not significant) in fluoride-treated rabbits. It is therefore concluded that long-term fluoride poisoning alters the calcium homeostatic mechanism, thereby affecting calcium metabolism.
本研究旨在确定慢性氟中毒对钙代谢的影响。将10只兔子每日口服10毫克氟化钠/千克体重的水溶液，持续18个月。在相同实验室条件下饲养的、数量相等（n = 10）的年龄、性别和体重匹配的兔子，但未用氟化钠溶液处理，作为对照。经氟处理的兔子的空腹血浆钙浓度显著低于对照动物（P < 0.001）。与血浆钙水平降低相反，在所有经氟处理的动物中均观察到肠道放射性钙（45Ca）吸收增加（P < 0.001）。然而，经氟处理的兔子的尿钙排泄水平降低（P = 无显著性差异）。因此得出结论，长期氟中毒会改变钙稳态机制，从而影响钙代谢。
